Dr. Nicola Mason Discusses CAR iNKT Cell Therapy Clinical Trial for Dogs with Osteosarcoma Lung Mets

Tripawd Talk Radio 130: In this inspiring episode of Tripawd Talk, we’re joined by Dr. Nicola Mason, a leading veterinary immunologist at the University of Pennsylvania, to discuss her groundbreaking work in treating osteosarcoma in dogs.

Dr. Mason explains how immunotherapy — specifically CAR T-cell therapy — is showing promise for dogs with metastatic bone cancer. You'll learn about a brand-new CAR iNKT cell therapy clinical trial using off-the-shelf donor immune cells to help dogs fight lung metastases after amputation and chemotherapy.

We also talk about the importance of immune system “fitness,” what researchers have learned from past clinical trials, and why the courage of pet parents participating in these studies is helping to advance care for both dogs and children with osteosarcoma.

Whether you’re facing a recent diagnosis or simply want to stay informed about the future of canine cancer care, this episode offers hope, insight, and valuable next steps.


GUEST BIO:
About Dr. Nicola Mason
Dr. Nicola Mason, BVetMed, PhD, DACVIM, FRCVS, is a professor of Professor of Medicine and Pathobiology at the University of Pennsylvania School of Veterinary Medicine. She a leading researcher in the field of veterinary immunotherapy.

Dr. Mason has pioneered groundbreaking cancer treatments for dogs, including immunotherapies that activate the body’s own immune system to fight osteosarcoma.

Her current research focuses on innovative cellular therapies, including CAR iNKT cell treatments designed to target metastatic disease. Dr. Mason’s work is helping shape the future of cancer care for both pets and people.

RESOURCES:
Mentioned in This Episode

New Clinical Trial at Penn Vet: Off-the-Shelf CAR T-Cell Therapy for Dogs with Osteosarcoma

https://tripawds.com/2025/07/17/penn-vet-clinical-trial-for-osteosarcoma-dogs/

Penn Vet Comparative Immunotherapy Program: 

https://www.vet.upenn.edu/research/centers-laboratories/research-laboratory/clinical-immunotherapy

PBS Feature with Dr. Mason
Shelter Me: The Cancer Pioneers
https://www.pbs.org/video/the-cancer-pioneers-jemhoc/

AVMA Animal Health Studies Database: https://ebusiness.avma.org/aahsd/study_search.aspx

Connect & Learn More
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https://tripawds.circle.so

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